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KMID : 0616120070380020176
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 2 p.176 ~ p.180
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(Hepatoprotective Constituents of Saururus chinensis Roots Against Tacrine-induced Cytotoxicity in Human Liver-derived Hep G2 Cells)
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Jeong Gil-Saeng
Li Bin
Lee Dong-Sung
Gwon Ji-Woong
Lee Hye-Suk
Gwon Tae-Oh
Kim Youn-Chul
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Abstract
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Five liglans, sauchinone (1), di-0-methyltetrahydrofuriguaiacin B (2), manassantin A (3), manassantin B (4) and saucerneol B (5), have been isolated from the MeOH extract of Saururus chinesis roots. The evaluation for protective effect of compounds 1-5 against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1,2, and 5 showed significant protective effects with the EC_{50} values of74.2{pm}0.9, 111.3{pm}0.8,64.3{pm}0.8 {mu}M, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC_{50} value of 86.2{pm}0.5 {mu}M.
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KEYWORD
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Saururus chinesis, Saururaceae, Hepatoprotective, Hep G2 Cells, Tacrine
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